Age-Related Differences in Plasma Proteins: How Plasma Proteins Change from Neonates to Adults

Age-Related Differences in Plasma Proteins: How Plasma Proteins Change from Neonates to Adults

The incidence of major diseases such as cardiovascular disease, thrombosis and cancer increases with age and is the major cause of mortality world-wide, with neonates and children somehow protected from such diseases of ageing. We hypothesized that there are major developmental differences in plasma proteins and that these contribute to age-related changes in the incidence of major diseases. We...

Age-Related Gene Expression Differences in Monocytes from Human Neonates, Young Adults, and Older Adults

A variety of age-related differences in the innate and adaptive immune systems have been proposed to contribute to the increased susceptibility to infection of human neonates and older adults. The emergence of RNA sequencing (RNA-seq) provides an opportunity to obtain an unbiased, comprehensive, and quantitative view of gene expression differences in defined cell types from different age groups...

Capillary Permeability to Plasma Proteins.

ACCORDING to the classical hypothesis of Starling (1896) the exchange of water and small lipid-insoluble molecules across the capillary membrane is largely governed by the balance between hydrostatic and colloid osmotic pressures, the existence of the latter being dependent upon relative impermeability of the capillary membrane to plasma proteins. Starling's concept has been verified by direct ...

Change in N-Glycosylation of Plasma Proteins in Japanese Semisupercentenarians

An N-glycomic analysis of plasma proteins was performed in Japanese semisupercentenarians (SSCs) (mean 106.7 years), aged controls (mean 71.6 years), and young controls (mean 30.2 years) by liquid chromatography/mass spectrometry (LC/MS) using a graphitized carbon column. Characteristic N-glycans in SSCs were discriminated using a multivariate analysis; orthogonal projections to latent structur...

The plasma Proteins